1st Specialization in Medical and Pharmaceutical Biotechnologies
Applied microbiology including laboratory
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ECTS Credits | 4 |
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Number of Hours (h/year) | 60 |
Teaching staff | [donnée non visible pour l'instant] |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_SGBM0009/1 |
Prerequisite | Advanced knowledge in general microbiology, biochemistry, physics, mathematics and general biology |
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Aims and Objectives | The aim of the course is to train the student with fermentors of different volumes and their use in biotechnological productions, including scale-up experiments, optimisation and Downstream processes, |
Description | Introduction and history of industrial microbiology Recent examples of biotechnological products Industrial microorganisms (characteristics and taxonomy) Production of fermented food and drinks , of vaccines... Microbial growth, equations of batch, fed-batch and continuous cultures Optimisation of biotechnological and pharmaceutical productions Laboratory: Biomass production of an E.coli strain in different fermentation conditions (substrates, anae-/aerobiosis, fermentor/culture vessels ) and metabolites analysis e.g. in order to produce beta-galactosidase Investigation of the impact of different parameters ( cell density, substrate concentration, ...)on the success of the fermentation e.g. yields. Use of direct and indirect sensors and liquid/gas chromatography techniques.Investigation of Kla factor. |
Bibliography | LARPENT-GOURGAUD M. et SANGLIER J.J., Biotechnologies, Principes et Méthodes, Ed. Doin, Coll. Biosciences et Techniques, 1992. PRESCOTT, HARLEY et KLEIN, Microbiologie, Ed. De Boeck Université, 1995. SCRIBAN R., Biotechnologie, Coll. Tec et Doc., Lavoisier, 1988. THONART P., Cours de Microbiologie Industrielle, ULg. BOURDRANT, CORRIEU et COULET, CAPTEURS ET MESURES EN BIOTECHNOLOGIE (1994), Ed. Tec & Doc, Lavoisier. R. D. SCHMID (2005), Atlas de poche de BIOTECHNOLOGIE et de GENIE GENETIQUE, Ed. FLAMMARION DENEUVILLE F., Génie Fermentaire, Travaux Pratiques, Ed. Doin, Coll. Biosciences et Techniques, 1991. Mc NEIL B. et HARVEY L.M., Fermentation, a Practical approach, Oxford Univ. Press, 1990. Revues "Pour la Science", "La Recherche" et "Biofutur", différents articles www.genie-bio.ac-versailles.fr/ressources/ressources.htm
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Teaching and Learning Methods | Tutorials Lectures with video illustration and slides. |
Assessment Methods | Oral examinations Continuous assessment Oral examinations and on-line documentation work ( internet). |
Notes | Yes |
Language | French |
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