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3rd Bachelor in Medical Biology - Cytology
ECTS Credits | Number of Hours (h/year) | |
---|---|---|
2 | 30 | |
1 | 15 | |
3 | 30 | |
3 | 40 | |
1 | 15 | |
2 | 25 | |
1 | 15 | |
1 | 15 | |
3 | 40 | |
1 | 15 | |
2 | 30 | |
3 | 40 | |
24 | 600 | |
1 | 15 | |
2 | 30 | |
10 | 10 |
Deontology and ethics
ECTS Credits | 1 |
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Number of Hours (h/year) | 15 |
Teaching staff | HEMELAERS, Laurent |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBM0038/3 |
Prerequisite | None |
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Aims and Objectives | To have a reflexion on deeds in the name of moral values in the professional frame. To take part of discussions about several society subjects |
Description | Stakes and current debates on ethics · Ethics : morale ; moral values ; types of values ; the morale of reason ; the morale and the justice. Deontology · Definition · History · Medical and paramedical deontology code Group works: GMO, clonage, animal experimentation, gene therapy, IVF |
Bibliography | Cours de déontologie de médecine, ULg Cours de déontologie de la section I.G., Haute Ecole André Vésale LELEU Y.H. et GENICOT G., Le droit médical, Ed. De Boeck Université. Les mots de la bioéthique, un vocabulaire encyclopédique, De Boeck Université METAYER M., La philosophie éthique, Edition Du Renouveau Pédagogique Québec |
Teaching and Learning Methods | Lectures Project or fieldwork |
Assessment Methods | Projects or practical work Continuous assessment |
Notes | In part |
Language | French |
Research methodology
ECTS Credits | 1 |
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Number of Hours (h/year) | 15 |
Teaching staff | BRUMIOUL, Dominique |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBM0039/3 |
Prerequisite | To be able to draft an experimental report ; know the different directions for subunit results ( tables, figures…). Minimal knowledge of technical English. |
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Aims and Objectives | To bring a scientific research at practical and theoretical levels ; to write resulting report. |
Description | Research and maintenance of information :
Planning of experimental work Drafting written report:
|
Bibliography | COUTURE M., FOURNIER R. P., La recherche en Science. Guide pratique pour les chercheurs, Ed. De Boeck Université, 1999. SALMI R., Lecture critique et rédaction médicale scientifique, Ed. Elsevier, 2ème éd., Paris, 2003 |
Teaching and Learning Methods | Lectures exercises. |
Assessment Methods | Written examinations Continuous assessment |
Notes | In part |
Language | French |
Seminars, placements
ECTS Credits | 24 |
---|---|
Number of Hours (h/year) | 600 |
Teaching staff | BRUMIOUL, Dominique |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBM0041/3 |
Prerequisite | Good integration of the theoretical and practical notions as regards fundamental and biomedical matters. Good practical know-how : work methodically, quickly and exactly. |
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Aims and Objectives | To allow students to become integrated into a routine or research laboratory team. To approach professional ground in a participative way and so, to facilitate the learning of new and improved technologies. With regard to field problems, to develop the initiative and critical mind necessary to the analytical verification and experimental results interpretation. |
Description | Half training courses are organized in a routine laboratory of medical analysises and include equally bacteriology, medical chemistry, hematology. Half training courses include the end-of-studies work. |
Bibliography | |
Teaching and Learning Methods | Laboratory work Practical activities – research on the field |
Assessment Methods | Placements Continuous assessment and reports |
Notes | No |
Language | French |
Thesis
ECTS Credits | 10 |
---|---|
Number of Hours (h/year) | 10 |
Teaching staff | BRUMIOUL, Dominique |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBM0042/3 |
Prerequisite | Course of research methodology. Practical know-how. |
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Aims and Objectives | To provide students with the opportunity to deepen a selected topic in and outside laboratory. |
Description | An important feature of the third year studies is a laboratory based project lasting 300 hours. The students choose a subject suggested by the person responsible for the university, clinical or industry laboratories, preferably of research. This project involves a literature research, a laboratory investigation and a written report. |
Bibliography | |
Teaching and Learning Methods | Practical activities – research on the field |
Assessment Methods | Presentation of a written and an oral work. |
Notes | No |
Language | French |
Medical chemistry
ECTS Credits | 3 |
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Number of Hours (h/year) | 30 |
Teaching staff | CHARLIER, Corinne |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBM0033/3 |
Prerequisite | Elementary knowledge of epidemiological statistics. Anatomy and physiology of main functions. Notions in pathologic physiology related to main systems. Analytical principles connected with different types of assays. |
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Aims and Objectives | To have a critical approach the results of the analyses. To know to analyze causes of a process out control. To be able to denounce drifts of analytical quality involving rejection of biological results. To prove of logic and initiative. |
Description | Theory interpretation of biological data at analytic, semiological and pathologic-physiological levels and about normal values. Glucide metabolism: pathogenesis and complications near diabetic end; biological exploration and therapeutic balance tests; assays. Lipid metabolism: serum lipidic compounds; normal metabolism; pathologic states; apoproteins; exploration tests. Protein metabolism: serum protein properties; physico-chemical and biological properties of main specific plasmatic proteins. Calcium and phosphorus function exploration: hormonal regulations; pathologic states; assays. Enzymatic functional exploration: effects of physico-chemicals parameters on enzymatic reaction; serum enzyme semiology; isoenzymes; asays. Renal function tests: homeostatic principles, investigation methods. Thyroid exploration: biochemistry and mode of action of thyroid hormones; assays. Liver function tests: pathologic states including viral hepatitis; tests. Cellular receptors: classification; internalization; pathologic states. Tumors markers: classification; semiology. Acid-basis equilibrium and blood gazes Clinical biology laboratories accreditation. |
Bibliography | BOREL J.P., Biochimie dynamique, Ed. Maloine, 1987 MARTIN D.W., Précis de Biochimie de Harper, Presses de l'Université Laval, Editions ESKA, 1985 RAWN J.D., Ed., Traité de Biochimie, De Boeck-Wesmael, 1990 WEINMAN S., La Biochimie de Lubert-Stryer, 3e Ed., Flammarion Médecine Sciences, 1992 |
Teaching and Learning Methods | Lectures |
Assessment Methods | Oral examinations |
Notes | Yes |
Language | French |
Bactériologie médicale
ECTS Credits | 2 |
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Number of Hours (h/year) | 30 |
Teaching staff | CARPENTIER, Michel |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBM0024/3 |
Prerequisite | Good knowledge of the courses of general microbiology of the 2nd year. |
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Aims and Objectives | To know the infections pathology, the germs of the infectious diseases and the diagnostic tests. |
Description | Indications about the taking of blood for the hemoculture, septicemias intra- or out hospital. Respiratory, urinary and gynecological infections Diagnosis of sexually transmitted diseases Meningitis Diagnossis of diarrhoea Food poisoning Anaerobic bacteria Hepatitis Mononucleosis syndrome Blood and tissular parasites Faecal parasites HIV |
Bibliography | Manual of clinical microbiology |
Teaching and Learning Methods | Lectures |
Assessment Methods | Oral examinations |
Notes | Yes |
Language | French |
Biosécurité
ECTS Credits | 1 |
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Number of Hours (h/year) | 15 |
Teaching staff | GRIGNET, Christine |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBM0025/3 |
Prerequisite | |
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Aims and Objectives | To protect the staff of laboratory in front of infectious organisms.To prevent the dissemination of biological agents.To respect the rules of safety. |
Description | Introduction:review of definitions. Infectious organisms. Infections acquired in laboratories. Structures affected and exposed staff. Origins and causes of infections. Intercourses of infections: oral, cutaneous, conjunctival, percutaneous, airborn; aerosols and penetration in the respiratory system. Evaluation of biological risks in laboratories. Classes of pathogen's risk and security sheets. Specific risks related to use of cell cultures. Specific risks related to OGM; potentialisation of risk outcomed from the nature of insert. Actions of prevention. Equipment of individual protection and equipments of security. Good practice of work. Management of waste. Levels of confinement (L1 to L4). The work with the animals and the animal houses. Physical and chemical inactivation of biological agents. The transport of biological agents. Legislations regarding biosecurity: execution and monitoring |
Bibliography | |
Teaching and Learning Methods | Lectures |
Assessment Methods | Oral examinations |
Notes | Yes |
Language | French |
Introduction to pathological anatomy examinations
ECTS Credits | 3 |
---|---|
Number of Hours (h/year) | 40 |
Teaching staff | THIRY, Albert |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBMCY0003/3 |
Prerequisite | Notions of biology, anatomy and physiology, pathological physiology, biochemistry, medical chemistry, histology including histological techniques, English, bibliographic research. |
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Aims and Objectives | To know, understand and realize pathological anatomy techniques |
Description | Definition of basic pathologic lesions : inflammation, infections; overload; necrosis ; tumors Different examinations in order to investigate a lesion : clinical examination; radiology; biopsies; surgical sampling; cytology and molecular biology. Different sampling : medical, surgical and radiologic biopsies; surgical pieces; cytologic punctures. Different pathological anatomy analysises: standard histology; histochemistry; immunohistology; histoenzymolgy; in situ hybridization; electronic microscopy; molecular biology. Surgical acts. |
Bibliography | DOMIZIO P. et LOWE D., Reporting Histopathology Sections, Chapman & Hall Medical, ISBN 0-412-43040-1 SANDRITTER W. et THOMAS C., Anatomie pathologique macroscopique manuel et atlas, Masson, ISBN 2-225-80399-4 |
Teaching and Learning Methods | Lectures |
Assessment Methods | Written examinations |
Notes | In part |
Language | French |
Surgical pathology (macroscopic)
ECTS Credits | 3 |
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Number of Hours (h/year) | 40 |
Teaching staff | THIRY, Albert |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBMCY0004/3 |
Prerequisite | Notions of biology, anatomy and physiology, pathological physiology, biochemistry, medical chemistry, histology including histological techniques, english, bibliographic research. |
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Aims and Objectives | Learning how to realize macroscopic sampling in pathological anatomy. |
Description | Macroscopic examinations : · Systematic applications in region: gastro-intestinal; gynecologic, otorhinolaryngologic, cardio-vascular, urologic, pulmonary, hematologic, osteoarticular. · International protocoles. · Formulation of protocole as regards macroscopic examination – visual illustrations. · Information research . Pathologic laboratory organization Quality control |
Bibliography | UNDERWOOD J.C.E., Introduction to biopsy interpretation and surgical pathology, Springer-Verlag, ISBN 3-540-17495-8 DOMIZIO P. et LOWE D., Reporting Histopathology Sections, Chapman & Hall Medical, ISBN 0-412-43040-1 SANDRITTER W. et THOMAS C., Anatomie pathologique macroscopique manuel et atlas, Masson, ISBN 2-225-80399-4 |
Teaching and Learning Methods | Lectures |
Assessment Methods | Written examinations |
Notes | In part |
Language | French |
Cytology and cytopathology including laboratory
ECTS Credits | 3 |
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Number of Hours (h/year) | 40 |
Teaching staff | THIRY, Albert |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBMCY0005/3 |
Prerequisite | Notions of biology, anatomy and physiology, pathological physiology, biochemistry, medical chemistry, histology including histological techniques, english, bibliographic research. |
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Aims and Objectives | To understand and to carry out cytologic preparations and sampling for specified cases by Royal Decrees. To read cytologic slides. |
Description | Cytology
Cytologic study applied to female genital tract, urinary system and respiratory tract:
Cytology of effusions and liquor cerebrospinalis:
Cytology of aspirates with fine needle:
Mammary gland cytology |
Bibliography | KEEBLER M.C. et SOMRAK M.T., The manual of cytotechnology, 7th Ed., ASCP Press, 1993, ISBN 0-89189-352-0 RAMZY I., Clinical cytopathology and aspiration biopsy, 2nd Ed., Mc Graw-Hill, 2001, ISBN 0-8385-1069-8 MAILLET M., LABBE S. et CHARASINI D., Cytologie gynécologique normale et pathologique, Piccin, 1991, ISBN 88-299-0965-3 UNDERWOOD J.C.E., Introduction to biopsy interpretation and surgical pathology, Springer-Verlag, ISBN 3-540-17495-8 |
Teaching and Learning Methods | Lectures |
Assessment Methods | Written examinations |
Notes | In part |
Language | French |
Cytogenetic techniques including laboratory work
ECTS Credits | 2 |
---|---|
Number of Hours (h/year) | 30 |
Teaching staff | HELLIN, Anne-Cécile |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBMCY0006/3 |
Prerequisite | Basic notions of genetics ( nucleic acids structure), protein synthesis ( transcription and traduction), genetic code, mitosis and meiosis, gametogenesis. |
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Aims and Objectives | To know and understand principles of techniques of cytogenetic (caryotype, FISH, MLPA). To have cytogenetic clinical notions. To interpret instructions of chromosomic analysis and to adapt detection technique to researched abnormalities. |
Description | Introduction
Theorical background : DNA ; genetic code; from DNA to protein ( transcription and translation); mitosis and meiosis, gametogenesis. Chromosomes : structure of chromosome ; definition of karyotype ; classification of chromosomes. The different samples and their indications: constitutional diagnosis; prenatal diagnosis; oncological diagnosis The different technics of treatment : culture of samples ; treatment of one sample to obtain metaphases; realization of a cellular pellet; techniques of banding; special stainings; observations with microscope; criterias of karyotype analysis and norms of good practise. Definition and classification of chromosomal abnormalities: numerical abnormalities; structural abnormalities; homogenous karyotype and mosaicism; chromosomal markers; chromosomal aberrations; chromosomal variants. Molecular cytogenetics: definition; principle; applications; evolution; protocol; kinds of chromosomal probes; special techniques. Constitutional chromosomal abnormalities: different syndromes ( Down, Edwards, Patau ,Turner and Klinefelter syndromes ; other abnormalities of sexual chromosomes ; microdeletion syndromes; syndromes of chromosomal instability. Acquired chromosomal abnormalities: genetic and cancer (genetic susceptibility to cancer; the multi-step process of cancer; acquired chromosomal abnormalities ). |
Bibliography | DE GROUCHY J. et TURLEAU C., Atlas des maladies chromosomiques, 2e Ed., 1982. OFFIT K., Clinical cancer genetics - Risk Counselling & Management, 1998. CZEPULKOWSKI B., Analyzing Chromosomes, 2001.
GARDNER R.J.M. & SUTHERLAND G.R., Chromosome Abnormalities and Genetic Counselling, 2nd Ed., 1996. GERSEN S.L. & KEAGLE M.B., The Principles of Clinical Cytogenetics, 1999. HARPER P.S., Practical Genetic Counselling, 1998. SCHINZEL A., Catalogue of Unbalanced Chromosome Aberrations in man, 2nd Ed., 2001. ROONEY D.E. & CZEPULKOWSKI B.H., Human Cytogenetics, 1994. ROONEY D.E., Human Cytogenetics - Malignancy and acquired abnormalities, 2001. ROONEY D.E., Human Cytogenetics - Constitutional analysis, 2001. VERMA R.S. & BABU A., Human Chromosomes - Manual of basic techniques, 1989. CLARK M.S. & WALL W.J., Chromosomes - The Complex Code, 1996. BONTHRON D., FITZPATRICK D., PORTEOUS M. & TRAINER A., Clinical Genetics - A case-based approach, 1998. HEIM S. & MITELMAN F., Cancer Cytogenetics - Chromosomal and Molecular Genetic Aberrations of Tumor Cells, 2nd Ed., 1995. MARK H.F.L., Medical Cytogenetics, 2000. KORF B.R., Human Genetics - A Problem-based Approach, 2nd Ed., 1999. |
Teaching and Learning Methods | Lectures Laboratory work Lectures (24 h) – Tutorials (6 h) |
Assessment Methods | Oral examinations + practical participation |
Notes | Yes |
Language | French |
Applied hematology
ECTS Credits | 2 |
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Number of Hours (h/year) | 25 |
Teaching staff | HEMELAERS, Laurent TASSIN, Françoise |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBMCY0008/3 |
Prerequisite | Basic notions of hematology courses of year 2 |
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Aims and Objectives | To have a good command of basic techniques in hematologic exploration To be able to do and to understand immunohematology techniques Recognize normal blood cells and numerate precisely Recognize young blood cells and name it |
Description | Study of a complete blood Study of blood groups · Test at the birth · Compatibility test · Cytologic approach of smears · Normal bloods and different cellular lineages The « traps « of normal bloods and some pictures of pathologic bloods. |
Bibliography | BESSIS M., Réinterprétation des frottis sanguins, Masson HEILNEYER L. et BEGEMANN H., Atlas of clinical hematology, Springer Verlag Cours d’hématologie, Haute Ecole André Vésale, 2e GBM |
Teaching and Learning Methods | Lectures Tutorials Tutorials (24 h). Lectures (6 h). |
Assessment Methods | Written and/or oral examination Projects or practical work |
Notes | In part |
Language | French |
Applied microbiology, laboratory
ECTS Credits | 2 |
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Number of Hours (h/year) | 30 |
Teaching staff | FRANCK, Marianne |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBMCY0009/3 |
Prerequisite | Courses of biochemistry, bacteriology and parasitology ( theory and practice) of 2nd year. |
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Aims and Objectives | To apply theoretical knowledge to understand to interpret ordered analysis ( uniray infections ).To apply critically practical methods. To evaluate the results in their whole to orientate the medical diagnosis. To interpret antibiograms. To organize and plan a laboratory work. |
Description | Review of basic techniques : culture media, sterile device, coloring, isolations, seedings. Identification of microorganisms (with Api 20E, Api 20 NE, Api Staph, Api Strep, Api 20 C AUX and Enterotubes) Analysis of urinary samples Antibiograms of urinary germs (Kirby-Bauer's method and ATB technique) |
Bibliography | BERCHE P. et al., Bactériologie, Flammarion Médecine-Sciences, 1988. AVRIL J.L., Bactériologie clinique, Ellipses, 1992. Presscott et al, Microbiologie, Ed. De Boeck, 2003 |
Teaching and Learning Methods | Laboratory work |
Assessment Methods | Written examinations Continuous assessment Rapport de laboratoire |
Notes | In part |
Language | French |
Introduction à la culture de cellules, laboratoires
ECTS Credits | 1 |
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Number of Hours (h/year) | 15 |
Teaching staff | DE RYCKER, Cécile |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBM0018/3 |
Prerequisite | Use of the microscope Aseptic rules
|
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Aims and Objectives | Use ot the phase-contrast microscope How to prepare culture medias Maintenance of cultures Subcultures Cell counting |
Description | |
Bibliography | |
Teaching and Learning Methods | Laboratory work |
Assessment Methods | Written examinations Continuous assessment |
Notes | In part |
Language | French |
Techniques appliquées à la cytologie
ECTS Credits | 1 |
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Number of Hours (h/year) | 15 |
Teaching staff | HEMELAERS, Laurent |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBMCY0007/3 |
Prerequisite | Background of hematology, cell dilution, cell numeration |
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Aims and Objectives | To understand flow cytometry To caracterize cell population on a dot plot To make cell isolation with density gradient (percoll) To put lymphocytes/monocytes in culture and interprete cell stimulatio with MTS |
Description | flox cytometry visit and theory in school Blood cells isolation and culture of lymphocytes/monocytes |
Bibliography | |
Teaching and Learning Methods | Tutorials Group seminars or workshops |
Assessment Methods | Written examinations Projects or practical work Continuous assessment |
Notes | In part |
Language | French |
Cell culture introduction
ECTS Credits | 1 |
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Number of Hours (h/year) | 15 |
Teaching staff | DE RYCKER, Cécile |
Course Unit | Compulsory |
Term | Quad. 1 and 2 |
Code | PARA-D_GBM0017/3 |
Prerequisite | Cell morphology and biology, aseptic rules. |
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Aims and Objectives | To learn the specific vocabulary of the disciplin. To know the usual techniques for the routine work in a cell culture laboratory. Appreciation of the advantages and dissadvantages of each technique. |
Description | The laboratory equipment. Aseptic techniques Preparations and sterilization. Contaminations of the cultures Protection - biohazard Culture conditions (media, pH, ...) Basic techniques |
Bibliography | FRESHNEY Ed., Culture of animal cells : a manual of basic technique, Liss, New York, 2005 FRESHNEY Ed., Animal cell culture : a pratical approach, IRL press, Oxford, 1989 ADOLPHE M. et BARLOVARZ-MEINON G., Culture de cellules animales : méthodologies, applications, INSERM, 1999. |
Teaching and Learning Methods | Lectures |
Assessment Methods | Written examinations |
Notes | Yes |
Language | French |
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